Endocrine Abstracts

Partial inhibition of PI3K is one of the best-validated and evolutionary conserved manipulations to extend longevity. PI3K is a master regulator of anabolism and the best validated beneficial effects of reduced PI3K are related to metabolism and include increased energy expenditure, reduced nutrient storage, and protection from obesity. We have found that a dual chemical inhibitor of the α and δ PI3K isoforms (CNIO-PI3Ki) reduces obesity in mice and monkeys, without ...

Objectives: To check possible advantages of ambulatory blood pressure monitoring (ABPM) in diagnosis and disease control respect to blood pressure conventional measurement ways.Also to study the circadian rhythm of each patient to detect higher cardiovascular risk situations.Material and methods: One hundred and nine patients were included in this study: 44% male, 56% female. ABPM were indicated in four different situations: hypert...

Introduction: Sarcopenia, an age-associated loss of skeletal muscle mass and function, has been related to higher mortality in general population as well as in HIV-infected patients. In elderly, sarcopenia is a marker of frailty. The aim of our study was to describe the prevalence of sarcopenia and related factors in HIV-infected population.Methods: Skeletal muscle mass (SMM), total fat mass and body fat distribution were measured by DXA scan. Muscle mas...